Thyrotropin Receptor Antibody, Serum
Also known as: LATS, Long-acting Thyroid Stimulator, TBII, Thyrotropin-binding Inhibitory Immunoglobulin, TRAb
Use
Diagnosis of hyperthyroidism and Graves' disease
Special Instructions
This test may show interference if the sample is collected from a person consuming a high dose of biotin supplements. It is advised to query patients about biotin intake and ask them to stop biotin consumption at least 72 hours before sample collection.
Limitations
The test may produce inaccurate results if the sample is lipemic, hemolyzed, or collected from a patient on heparin therapy. Citrate plasma is not an acceptable specimen type. While this test is a valuable diagnostic tool for Graves' disease and hyperthyroidism, its accuracy can be compromised by improper specimen handling and environmental factors affecting sample integrity.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 5385-0
- 5385-0
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL
Container
Gel-barrier tube (preferred) or red-top tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Patient Preparation
Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Storage Instructions
Refrigerate.
Causes for Rejection
Citrate plasma specimen; samples collected in heparin or samples from patients on heparin therapy; lipemic or hemolyzed serum samples; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unstable |
| Refrigerated | 6 days |
| Frozen | 12 months |