Tickborne Disease Antibody Profile, Serum
Also known as: Anaplasmosis, Babesiosis, Ehrlichiosis, Lyme, Lyme disease
Use
This test is used for evaluation of patients with a history of, or suspected, tick exposure who are presenting with fever, myalgia, headache, nausea and other nonspecific symptoms. Evaluation of infection with the most common tickborne diseases found in the United States, including Lyme disease (Borrelia burgdorferi), ehrlichiosis (Ehrlichia chaffeensis), anaplasmosis (Anaplasma phagocytophilum) and babesiosis (Babesia microti).
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply. Specimens that are not collected or stored correctly, such as grossly hemolyzed or lipemic samples, may be rejected.
Limitations
Screening of the general population should not be performed. The positive predictive value depends on the likelihood of tickborne disease presence. Testing is indicated only for patients with clinical symptoms of tickborne disease or when exposure is suspected. In general, IgM tests should be disregarded if symptoms persist for more than 30 days; only IgG results should be interpreted. Potential assay interference can occur due to circulating antibodies from other infections like Human Ehrlichiosis (HE), Tick-borne Relapsing Fever (TBRF), Babesiosis, Parvovirus, and EBV. Results should be interpreted with caution in these patients.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 103603-7
- 83081-0
- 16117-4
- 47405-6
- 23877-4
- 8251-1
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL
Container
Red-top tube, gel-barrier tube or serum transfer tube
Collection Instructions
If tube other than a gel-barrier tube is used, transfer separated serum to a plastic transport tube. Do not submit frozen gel-barrier tubes; spin down and transfer separated serum to a plastic transport tube prior to freezing.
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; gross lipemia; samples containing particulate matter or exhibiting obvious microbial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |