Tissue Transglutaminase (tTG), IgA
Use
Detection of antibodies to aid in the diagnosis of gluten-sensitive enteropathy (GSE), such as celiac disease and dermatitis herpetiformis
Special Instructions
Studies have demonstrated that IgA endomysial antibody tests have greater than 99% specificity for gluten-sensitive enteropathy. This high specificity is due to the identification of tissue transglutaminase (tTG) as the endomysial antigen.
Limitations
A negative tTG IgA result in an untreated patient does not rule out gluten-sensitive enteropathy (GSE). This can often be explained by selective IgA deficiency, which is a relatively frequent finding in patients with celiac disease. Therefore, results from this assay should be interpreted in conjunction with the overall clinical presentation and results from other serological tests.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 31017-7
- 31017-7
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Specimen should be free of bacterial contamination, hemolysis, and lipemia.
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |