Transferrin
Also known as: Siderophilin
Use
Increased in iron deficiency anemia. It is decreased in chronic inflammatory states, hereditary atransferrinemia, some instances of acquired liver disease, neoplasia, and renal disease. Transferrin is an index of nutritional status.
Special Instructions
Transferrin is responsible for 50% to 70% of the iron binding capacity of serum, distinctly different from TIBC. The protein is synthesized mainly by the liver, and there are over 20 genetic variants of transferrin. It is approximately one-third saturated in normal states and contributes to circadian variations in serum iron levels.
Limitations
Transferrin levels can be artificially increased in patients on oral contraceptives and those in late pregnancy. Furthermore, in cases of severe protein malnutrition, such as kwashiorkor, transferrin may not be elevated even in iron-deficient states.
Methodology
Immunoassay (Immunologic)
Biomarkers
LOINC Codes
- 3034-6
- 3034-6
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
Not provided
Container
Gel-barrier tube, red-top tube, or green-top (heparin) tube; do not use EDTA plasma.
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |