UGT1A1 Irinotecan Toxicity
Also known as: Camptosar®, Irinotecan
Use
Irinotecan (Camptosar®) is used, or under evaluation, in a broad spectrum of solid tumors, and is often prescribed for treating patients with metastatic cancer of the colon or rectum, especially when 5-fluorouracil treatment has not been entirely successful. Severe toxicity (eg, grade 4 neutropenia) is commonly observed in cancer patients receiving irinotecan who carry the UGT1A1*28 allele, also called TA. This test result will provide valuable information to physicians prior to initiating or modifying treatment or supplementing treatment with additional drugs.
Special Instructions
Not provided.
Limitations
The test exclusively detects variants at the TATA box polymorphism of the UGT1A1 gene, specifically the (TA)5, (TA)6, (TA)7, and (TA)8 alleles. Other polymorphisms in the UGT1A1 gene will not be detected. Additionally, the G71R (*6) variant, which is significant in Asian patients with Gilbert syndrome, is not detected by this assay. This test has not been cleared or approved by the FDA.
Methodology
PCR-based (PCR)
Biomarkers
No genes
Gene
LOINC Codes
- 41044-9 - UGT1A1 gene Mut Anl Bld/T
- 41044-9 - UGT1A1 gene Mut Anl Bld/T
- 72486-4 - Lab director name Provider
- 8262-8 - Service Cmnt 02-Imp
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
Lavender-top (EDTA) tube, yellow-top (ACD) tube
Collection Instructions
Collect specimen in a lavender-top (EDTA) or yellow-top (ACD) tube. Ship at room temperature or frozen.
Storage Instructions
Maintain at room temperature for 7 days, refrigerated for 1 month, or frozen for 2 years.
Causes for Rejection
Hemolysis; quantity not sufficient for analysis; improper container
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 1 month |
| Frozen | 2 years |
Other tests from different labs that may be relevant