von Willebrand Factor (vWF) Multimers
Also known as: vWF Multimers
Use
Aid in the determination of von Willebrand factor (vWF) deficiency subtype6-9
Special Instructions
Bleeding symptoms in vWD patients can vary, even among family members with the same defect. It is essential to distinguish between von Willebrand disease and hemophilia A due to different treatments. Acquired vWF deficiency is rare but under-reported and linked with certain autoimmune, clonal proliferative conditions, and specific diseases. Autoantibodies can cause vWD in elderly individuals with certain disorders.
Limitations
Acquired von Willebrand disease had been reported with autoimmune conditions. Distinguishing between von Willebrand disease and other conditions with similar bleeding symptoms is crucial as treatments differ. Pre-analytical handling issues, such as improper storage or handling of samples, may cause inaccurate results. Repeat analysis with proper handling is recommended for accurate diagnosis.
Methodology
Immunoassay (Western Blot)
Biomarkers
LOINC Codes
- 6013-7
- 6013-7
Result Turnaround Time
4-10 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
1 mL
Container
Blue-top (sodium citrate) tube
Collection Instructions
Collect blood in a blue-top tube (3.2% buffered sodium citrate). Ensure proper blood to anticoagulant ratio; mix immediately by gentle inversion at least six times. No discard tube required prior to collection. Handle noncitrate tubes accordingly, and centrifuge to carefully remove plasma. Transfer into a Labcorp PP transpak frozen purple tube and freeze immediately. Ensure separate specimens for multiple tests.
Patient Preparation
Do not draw from an arm with a heparin lock or heparinized catheter.
Storage Instructions
Freeze.