17-Hydroxypregnenolone, Serum
Use
This test is useful for confirming a diagnosis of 3-beta-hydroxysteroid dehydrogenase deficiency and as an ancillary test for congenital adrenal hyperplasia (CAH), particularly when a diagnosis of 21- and 11-hydroxylase deficiency has been ruled out. It is also part of a battery of tests used to evaluate women with hirsutism or infertility, which can result from adult-onset CAH.
Special Instructions
Not provided.
Limitations
The test is not cleared or approved by the FDA but is developed in a manner consistent with CLIA requirements. It does not undergo full FDA review and is labeled as an Analyte Specific Reagent (ASR) product.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
17-Hydroxypregnenolone
Analyte
LOINC Codes
- 6765-2 - 17OH-Preg SerPl-mCnc
- 6765-2 - 17OH-Preg SerPl-mCnc
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial. Preferred collection container is a red top tube; serum gel is acceptable.
Causes for Rejection
Gross hemolysis, gross lipemia, and gross icterus are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 28 days |
| Frozen | 28 days |