18-Hydroxycorticosterone, Serum
Use
The 18-Hydroxycorticosterone test measures the level of 18-hydroxycorticosterone in the serum, which can be used in the evaluation of patients with suspected primary hyperaldosteronism or other disorders related to abnormal steroid production. This hormone is a precursor in steroid biosynthesis and its measurement can provide insights into adrenal gland function and hormone regulation.
Special Instructions
Serum must be separated from cells within 45 minutes of venipuncture. Ensure serum is frozen before submission in a plastic vial.
Limitations
The test may not be suitable for patients who cannot provide sufficient serum volume for analysis. Hemolysis, lipemia, and icterus in the specimen can potentially interfere with test results. The test requires careful handling and storage of the specimen to maintain its stability and ensure accurate results, especially given the long stability requirements for frozen samples.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 1674-1
- 1674-1
Result Turnaround Time
7-16 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Plastic vial
Collection Instructions
Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Serum must be separated from cells within 45 minutes of venipuncture. Centrifuge and send 3 mL of serum frozen in a plastic vial.
Storage Instructions
Serum should be frozen for up to 90 days, refrigerated for 24 hours, or kept at room temperature for 24 hours.
Causes for Rejection
Specimens other than serum or plasma EDTA or green-top heparin
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 24 hours |
| Frozen | 90 days |