6-Monoacetylmorphine (6-MAM), Confirmation, Meconium
Use
This test is used for the detection of in utero heroin exposure up to 5 months before birth. Heroin, which is not clinically used in the United States, is metabolized into 6-monoacetylmorphine (6-MAM), a unique metabolite that indicates heroin use. Detection of 6-MAM in meconium indicates heroin use by the mother. Opiates, including heroin, readily cross the placenta, potentially causing harm to the developing fetus.
Special Instructions
Not provided.
Limitations
The detection of 6-MAM may be prevented by its short half-life and stability. Detection relies on the presence of 6-MAM in meconium, which may degrade or convert to morphine if not properly handled. Positive results provide a definitive indication of heroin use, as 6-MAM is the only unique marker of heroin, but negative results do not rule out use.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
6-Monoacetylmorphine
Analyte
LOINC Codes
- 29345-6 - 6MAM Mec-mCnt
- 29345-6 - 6MAM Mec-mCnt
- 69050-3 - Toxicologist review
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Stool
Volume
1 g (approximately 1 teaspoon)
Minimum Volume
0.3 g (approximately 1/4 teaspoon)
Container
Stool container
Collection Instructions
Collect entire random meconium (newborn's first bowel movements) specimen. Send specimen frozen.
Storage Instructions
When refrigerated, a significant percentage of 6-monoacetylmorphine will convert to morphine in less than 24 hours.
Causes for Rejection
Grossly bloody; Reject; Pink OK. Stool; diapers.
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |