Acetylcholine Receptor Modulating Antibody, Flow Cytometry Assay, Serum
Use
This test is useful for diagnosing autoimmune myasthenia gravis (MG) in adults and children. It helps distinguish autoimmune from congenital MG in adults and children, as well as other acquired neuromuscular junction transmission disorders. The test is a qualitative assay and should not be used for monitoring purposes.
Special Instructions
Not provided.
Limitations
Results should be interpreted in the appropriate clinical and electrophysiological context and are not diagnostic in isolation. Positive results may be found in some patients with Lambert-Eaton syndrome, paraneoplastic CNS and PNS autoimmune disorders, and in healthy individuals. Hemolysis, muscle-relaxant drugs used in general anesthesia, or serum exposed to high ambient temperature can cause false-positive results. Negative results do not exclude MG diagnosis, and if clinical suspicion persists, retesting may be necessary.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
Acetylcholine Receptor (AChR)
Protein
LOINC Codes
- 99062-2 - AChR Mod Ab Ser Ql FC
- 99062-2 - AChR Mod Ab Ser Ql FC
Result Turnaround Time
5-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Storage Instructions
Refrigerated (preferred) for 28 days, ambient for 72 hours, or frozen for 28 days.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |