Activated Partial Thromboplastin Time (APTT) Mix 1:1, Plasma
Use
The activated partial thromboplastin time (APTT) mixing test is performed to evaluate a prolonged APTT test result, particularly in differentiating coagulation factor deficiencies from inhibitors. It measures the integrity of the intrinsic and common coagulation pathways and aids in identifying congenital or acquired factor deficiencies, as well as detecting the presence of inhibitors such as lupus anticoagulant. The test is useful for screening coagulation factor deficiencies and detecting coagulation inhibitors.
Special Instructions
The test is only orderable as a reflex part of profiles such as the Lupus Anticoagulant Profile or the Bleeding Diathesis Profile, and not as a standalone order. Clinicians should consult these profiles for comprehensive testing and interpretation guidance.
Limitations
APTT testing, including the mixing study, will not detect all types of lupus anticoagulants or coagulation inhibitors. Specimens with lipemia may interfere with the assay. The APTT mixing study may not detect weak inhibitors and is not indicated for specimens with a normal APTT. Mild coagulation factor deficiencies may not result in a significant prolongation of the APTT.
New York Approved
Methodology
Other (Optical Clot-Based)
Biomarkers
LOINC Codes
- 5946-9
- 5946-9
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
The test is only performed using plasma mixed with a reagent and incubated under specified conditions. Ensure the specimen is frozen if not tested immediately.
Causes for Rejection
Gross hemolysis, gross lipemia, and gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |