Adaptor Protein 3 Beta2 (AP3B2) Antibody, Tissue Immunofluorescence Titer, Serum
Use
AP3B2 (adaptor protein 3 beta2)-IgG is a marker of autoimmune disorder characterized by gait instability and neurological dysfunction like cerebellar or sensory ataxia. Treatment following detection might lead to improvement as AP3B2 autoimmunity, though rare, is a potentially manageable condition. Primarily used for diagnosing patients presenting with mixed cerebellar and sensory ataxia and myeloneuropathy by reporting an end titer result from serum specimens.
Special Instructions
The test is only orderable as a reflex in case the indirect immunofluorescence (IFA) pattern indicates AP3B2-IgG. Additional tests, such as AP3B2 antibody cell-binding assay (CBA), will incur extra charges. The assay uses mouse cerebellum, kidney, and gut tissue sections for testing the specimen.
Limitations
A negative test result does not exclude the possibility of neurological autoimmunity or the presence of cancer. The test depends on accurate collection and handling of serum samples. Coexisting non-neuron-specific autoantibodies can interfere with results but may be mitigated through serologic absorption.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence Assay (IFA))
Biomarkers
LOINC Codes
- 101908-2
- 101908-2
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Only orderable as a reflex. For more information see related autoimmune/paraneoplastic evaluations.
Causes for Rejection
Gross hemolysis, gross lipemia, or gross icterus.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 28 days |
| Frozen | 28 days |