Adenosine Deaminase, Pericardial Fluid
Use
The measurement of Adenosine Deaminase (ADA) activity in pericardial fluid can be useful in differentiating tuberculous pericarditis from other causes of pericarditis. Elevated levels of ADA in pericardial fluid may suggest an inflammatory condition such as tuberculosis, especially in regions where this disease is prevalent. ADA testing provides a non-invasive diagnostic tool that can inform clinical decision-making and potentially guide treatment.
Special Instructions
Indicate source of the specimen on the requisition form. Centrifuge pericardial fluid at ambient temperature before transferring 0.5 mL of the supernatant into a plastic vial. The specimen must remain frozen until received by the laboratory. Use a leak-proof container for collection and a plastic vial for submission. Proper handling ensures test accuracy.
Limitations
This test has been developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. Results should be interpreted in conjunction with other clinical findings and additional laboratory tests. The accuracy of ADA level measurements can be influenced by specimen handling and storage conditions. Care must be taken to freeze the sample immediately and maintain it until testing. Potential pre-analytical errors include improper centrifugation and delay in freezing, which may impact the reliability of results.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 49760-2
- 49760-2
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Body Fluid
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Leak-proof container, Plastic vial
Collection Instructions
Centrifuge pericardial fluid at ambient temperature. Transfer 0.5 mL of supernatant into a plastic vial and freeze. Indicate source on requisition.
Storage Instructions
Specimen must remain frozen until received at performing lab.
Causes for Rejection
Bronchoalveolar lavage (BAL), Glass tubes, Turbid specimens, Whole blood
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 30 days |