Aldosterone, Left Adrenal Vein, Serum
Use
Investigation using left adrenal vein specimen for primary aldosteronism such as adrenal adenoma/carcinoma and adrenal cortical hyperplasia, as well as for secondary aldosteronism including renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, and Bartter syndrome.
Special Instructions
Patient should discontinue spironolactone (Aldactone) 4 to 6 weeks before specimen collection. Plasma renin activity cannot be interpreted if the patient is being treated with spironolactone. Collection is recommended at 8 a.m. after the patient is active for approximately 2 hours.
Limitations
Late p.m. levels can be up to 30% lower compared to early a.m. levels. Supine values are on average 50% lower than upright collections. Sodium-deplete patients have significantly elevated serum aldosterone levels. For accurate results, it is advised to measure PRA concomitantly. ACE inhibitors can affect PRA levels and SA/PRA ratios, potentially affecting the diagnosis of primary aldosteronism.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 1763-2
- 1763-2
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.8 mL
Minimum Volume
1 mL
Container
Plastic vial
Collection Instructions
Preferred collection container is a red top tube; acceptable is serum gel. Centrifuge and aliquot serum into a plastic vial. Collect at 8 a.m., after the patient is active for approximately 2 hours. Collect no later than 10 a.m.
Patient Preparation
Discontinue spironolactone (Aldactone) for 4 to 6 weeks before collection. Ensure patient is active for 2 hours before collection.
Causes for Rejection
Gross hemolysis, lipemia, and icterus are acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 28 days |
| Frozen | 30 days |