Aldosterone, Plasma
Use
Investigation of primary aldosteronism, such as adrenal adenoma/carcinoma and adrenal cortical hyperplasia, as well as secondary aldosteronism including conditions like renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, and Bartter syndrome.
Special Instructions
Collection should occur around 8 a.m. after the patient has been active for approximately 2 hours. Specimens should be collected no later than 10 a.m. It's crucial to follow the detailed instructions available in the 'Renin-Aldosterone Studies' PDF. If not ordering electronically, complete the Renal Diagnostics Test Request form and send it with the specimen.
Limitations
Plasma renin activity cannot be interpreted if the patient is being treated with spironolactone. Spironolactone should be discontinued 4 to 6 weeks prior to testing. Late p.m. levels can be significantly lower than early a.m. levels, and supine values are generally lower than upright collections. Sodium-deplete subjects may have elevated plasma aldosterone levels.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 1763-2
- 1763-2
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
1.2 mL
Container
Plastic vial
Collection Instructions
Collect using a lavender top (EDTA) tube. Follow the collection time recommendations: collect around 8 a.m. after 2 hours of activity; do not collect later than 10 a.m. Centrifuge and aliquot plasma into a plastic vial.
Causes for Rejection
Gross hemolysis OK, Gross lipemia OK, Gross icterus OK
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 28 days |
| Frozen | 30 days |