Alpha-1-Antitrypsin, Serum
Use
This test is useful for the workup of individuals with suspected disorders such as familial chronic obstructive lung disease and diagnosing alpha-1-antitrypsin deficiency. Alpha-1-antitrypsin (A1A) is the most abundant serum protease inhibitor, inhibiting trypsin and elastin as well as several other proteases to prevent tissue damage by proteolytic enzymes. Deficiency in A1A is associated with early-onset emphysema and an increased risk of neonatal hepatitis, progressing to cirrhosis.
Special Instructions
If not ordering electronically, complete and send one of the following with the specimen: Gastroenterology and Hepatology Test Request (T728) or General Request (T239). For more algorithmic guidance, refer to 'Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm.'
Limitations
Low alpha-1-antitrypsin levels can result from liver disease, necessitating A1A proteotype testing to confirm deficiency. As an acute-phase reactant, A1A levels rise during inflammatory processes. Lipemic sera may affect nephelometric quantitation due to light scattering, leading to variable analysis results.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Nephelometry)
Biomarkers
LOINC Codes
- 6771-0
- 6771-0
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial. Accept either a red top or serum gel container.
Causes for Rejection
Gross lipemia will lead to rejection.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |