Alveolar Rhabdomyosarcoma (ARMS), 13q14 (FOXO1 or FKHR) Rearrangement, FISH, Tissue
Use
This test is useful for supporting the diagnosis of alveolar rhabdomyosarcomas (ARMS) in conjunction with an anatomic pathology consultation. ARMS are a subtype of rhabdomyosarcomas that are more common in older children and associated with a higher stage disease and an unfavorable prognosis. Most cases of ARMS are linked to the rearrangement of the FOXO1 gene on chromosome 13. Detection of FOXO1 rearrangement by FISH can help support a histologic diagnosis of ARMS.
Special Instructions
Not provided.
Limitations
This test is not approved by the US Food and Drug Administration and should be used as an adjunct to existing clinical and pathologic information. The FISH assay does not exclude other chromosomal abnormalities nor is it successful with non-formalin fixed specimens or decalcified tissues, which have approximately a 50% success rate. Testing may be canceled if insufficient tumor is available.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
No genes
Gene
LOINC Codes
- 93807-6 - FOXO1 gene Rear Tiss FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 80398-1 - Unique ID Current sample
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 18771-6 - Provider signing name
- 62364-5 - Test performance info Spec
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Submit a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block. Blocks prepared with alternative fixation methods are less favorable for successful results by FISH testing.