Apolipoprotein E Genotyping, Blood
Use
Determining specific apolipoprotein E (APOE) genotypes is useful for diagnosing individuals with type III hyperlipoproteinemia and assessing risk in individuals treated with B-amyloid-targeting antibodies for Alzheimer's disease. APOE genotyping is also associated with Alzheimer's susceptibility, although not recommended for predictive testing due to limited utility.
Special Instructions
Not provided.
Limitations
This assay does not identify all genetic variants causing type III hyperlipoproteinemia. Rare polymorphisms may result in false negatives/positives. The test cannot predict or exclude Alzheimer disease development. Interpretation requires clinical correlation due to potential discrepancies from rare alleles or DNA quality.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
APOE
Gene
LOINC Codes
- 42315-2 - APOE allele e2+e3+e4 Bld/T
- 50397-9 - Mol dx interp Bld/T Ql
- 42315-2 - APOE allele e2+e3+e4 Bld/T
- 69047-9 - Geneticist review
- 42349-1
- 31208-2 - Specimen source
- 18771-6 - Provider signing name
Result Turnaround Time
6-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
Not provided
Container
Lavender top (EDTA) or yellow top (ACD)
Collection Instructions
Invert several times to mix blood. Send whole blood specimen in the original tube. Do not aliquot.
Patient Preparation
A previous bone marrow transplant from an allogenic donor will interfere with testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 4 days |
| Frozen | 4 days |