Arbovirus Antibody Panel, IgG and IgM, Spinal Fluid
Use
This test aids in the diagnosis of arboviral encephalitis, specifically due to California (LaCrosse), St. Louis, Eastern equine, or Western equine encephalitis viruses. Arboviral infections can cause central nervous system infections leading to neurological symptoms in humans, which makes detection crucial for managing patient care. The test detects the presence of antibodies in cerebrospinal fluid (CSF), suggesting an ongoing or past infection. However, serological results should be interpreted alongside clinical findings as CSF antibodies may result from a breakdown in the blood-brain barrier or introduction of blood into CSF during lumbar puncture.
Special Instructions
Not provided.
Limitations
False-positive results may occur due to blood contamination during sample collection or a compromised blood-brain barrier. There's cross-reactivity potential with dengue fever virus in tests for St. Louis encephalitis, and some cross-reactivity between Eastern and Western equine encephalitis viruses. Further virus identification may require consideration of the patient's travel history and epidemiological data. Moreover, the test is not FDA cleared or approved, suggesting use under specific clinical contexts dictated by CLIA regulations.
Methodology
Immunoassay (Immunofluorescence Assay)
Biomarkers
LOINC Codes
- 49094-6 - Arbovirus IgG+IgM Pnl CSF IF
- 9539-8 - LACV IgG Titr CSF IF
- 9540-6 - LACV IgM Titr CSF IF
- 10897-7 - EEEV IgG Titr CSF IF
- 10899-3 - EEEV IgM Titr CSF IF
- 21509-5 - SLEV IgG Titr CSF IF
- 21510-3 - SLEV IgM Titr CSF IF
- 9315-3 - WEEV IgG Titr CSF IF
- 9316-1 - WEEV IgM Titr CSF IF
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
0.7 mL
Minimum Volume
0.7 mL
Container
Sterile vial (preferred: vial number 2)
Collection Instructions
Submit specimen collected in vial 2, if possible. If not, note which vial from which the aliquot was obtained.
Causes for Rejection
Gross hemolysis and gross lipemia are acceptable; however, no specific rejection conditions indicated.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 14 days |