Autoimmune Liver Disease Panel, Serum
Use
This panel is used for evaluating patients with suspected autoimmune liver disease, specifically conditions like autoimmune hepatitis or primary biliary cholangitis. It helps in the diagnostic workup of liver disease of unknown etiology and assesses the presence of specific liver-related autoantibodies. The panel includes testing for antinuclear antibodies (ANA), anti-mitochondrial antibodies (AMA), and smooth muscle antibodies (SMA), which are significant in diagnosing autoimmune hepatitis and primary biliary cholangitis.
Special Instructions
Not provided.
Limitations
The presence of smooth muscle antibodies (SMA), antinuclear antibodies (ANA), and antimitochondrial antibodies (AMA) should not be solely relied on for diagnosing autoimmune liver diseases. Positive results can occur in other conditions such as drug exposure-related hepatitis or CREST syndrome. Autoantibodies are not specific and should be interpreted in the context of clinical presentation and liver disease parameters. The test does not indicate the stage or prognosis of the disease nor is it suited for monitoring disease progression.
New York Approved
Methodology
Immunoassay (EIA)
Biomarkers
LOINC Codes
- 94700-2 - Liver diseases autoimmune Ab pnl SerPl
- 51715-1 - Mitochondria M2 Ab Ser IA-aCnc
- 59069-5 - ANA Ser Ql HEp2 subst
- 33253-6 - ANA Titr Ser HEp2 subst
- 49311-4 - ANA Pat Ser IF-Imp
- 26971-2 - Smooth muscle Ab Ser Ql IF
Result Turnaround Time
3-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
1.1 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, heat-treated specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 21 days |
| Frozen | 21 days |