B-Cell Acute Lymphoblastic Leukemia/Lymphoma (ALL), FISH, Adult, Varies
Use
This test detects common chromosome abnormalities associated with B-cell acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) in adult patients. It serves as adjunctive support to conventional chromosome studies and is particularly useful for evaluating specimens where chromosome studies have been unsuccessful. It employs a laboratory-designated probe set algorithm to assist in diagnosing recurrent cytogenetic changes indicative of certain prognostic outcomes, providing critical information for treatment strategy, including the potential need for early transplantation in cases with adverse prognosis markers such as BCR::ABL1 fusion.
Special Instructions
Not provided.
Limitations
Fluorescence in situ hybridization (FISH) should not replace conventional chromosome studies as it might miss chromosomal abnormalities linked to other hematological conditions. The test is not approved by the FDA for clinical use, emphasizing the need to correlate results with other clinical and pathologic information for comprehensive diagnosis. A failure to detect an abnormal clone does not exclude the presence of the disorder.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 102099-9 - B-cell ALL Bld/T FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD), Green top (sodium heparin), or Lavender top (EDTA)
Collection Instructions
Send the first aspirate, mix by inversion, and transport in the original tube unaliquoted.
Storage Instructions
Preferably at ambient temperature for transport.
Causes for Rejection
Fresh tissue