B-Cell Acute Lymphoblastic Leukemia/Lymphoma (ALL), FISH, Adult, Varies

Casandra

Casandra Test Code MC77471Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID BALAFCPT Codes 88271, 88275, 88291

B-Cell Acute Lymphoblastic Leukemia/Lymphoma (ALL), FISH, Adult, Varies

Clinical Use

Use

This test detects common chromosome abnormalities associated with B-cell acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) in adult patients. It serves as adjunctive support to conventional chromosome studies and is particularly useful for evaluating specimens where chromosome studies have been unsuccessful. It employs a laboratory-designated probe set algorithm to assist in diagnosing recurrent cytogenetic changes indicative of certain prognostic outcomes, providing critical information for treatment strategy, including the potential need for early transplantation in cases with adverse prognosis markers such as BCR::ABL1 fusion.

Special Instructions

The test is performed on adult patients aged 31 years or older with B-cell acute lymphoblastic leukemia/lymphoma. It is not intended for screening residual disease. Special conditions apply if a bone marrow transplant from the opposite sex has occurred or if the patient has Down syndrome. The FISH panel should encompass the entire B-ALL/LBL panel for adults, with specimen collection ideally being the first marrow aspiration. The specimen must not be aliquoted.

Limitations

Fluorescence in situ hybridization (FISH) should not replace conventional chromosome studies as it might miss chromosomal abnormalities linked to other hematological conditions. The test is not approved by the FDA for clinical use, emphasizing the need to correlate results with other clinical and pathologic information for comprehensive diagnosis. A failure to detect an abnormal clone does not exclude the presence of the disorder.

Test Details

New York Approved