B-Cell Lymphoma, Specified FISH, Varies
Use
This test is useful for detecting common chromosome abnormalities associated with specific B-cell lymphoma subtypes using client-specified fluorescence in situ hybridization (FISH) probes. It assists in the diagnosis and prognosis of mature B-cell lymphomas by identifying recurrent gene rearrangements, serving as important prognostic markers.
Special Instructions
This test should only be ordered if the sample is known to have a sufficient clonal B-cell population. If a flow cytometry result is available and does not identify a sufficient clonal B-cell population, the test order will be canceled. The test is not intended as a panel test; specific probes or suspected B-cell lymphoma subtype must be listed in the probe request field.
Limitations
The test is not approved by the US Food and Drug Administration and should be used as an adjunct to clinical and pathologic information. If no FISH signals are observed post-hybridization, the case will be released with a lack of FISH results. The absence of an abnormal clone does not rule out the presence of lymphoma or another neoplastic disorder.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101920-7
- 50397-9
- 69965-2
- 93356-4
- 62356-1
- 42349-1
- 78040-3
- 31208-2
- 85069-3
- 48767-8
- 62364-5
- 18771-6
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
1 mL
Container
Yellow top (ACD), Green top (sodium heparin), Lavender top (EDTA)
Collection Instructions
Preferably send the first aspirate from bone marrow collection, invert to mix, send in original tube, do not aliquot.
Causes for Rejection
Fresh tissue