Benztropine (Cogentin), Serum
Use
Benztropine is primarily used in the management of symptoms associated with Parkinson's disease and neuropathic disorders. It acts by balancing neurotransmitters in the brain, specifically by targeting the cholinergic and dopaminergic pathways. Measuring the serum concentration of Benztropine aids in therapeutic drug monitoring to ensure effectiveness and to prevent toxicity.
Special Instructions
This test is essential for patients undergoing treatment with Benztropine to maintain appropriate therapeutic levels. It requires careful collection and handling, adhering to specific specimen requirements to ensure valid test results.
Limitations
The test is sensitive to improper specimen handling and transport conditions. Hemolysis, lipemia, and icterus may interfere with the test results, potentially leading to inaccurate measurement of the drug concentration. This test does not provide information on patient compliance or predict clinical outcome solely based on serum levels.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 9384-9
- 9384-9
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
0.3 mL
Container
Green-top (sodium heparin) tube
Collection Instructions
Spin down and send 2 mL sodium heparin plasma refrigerated in a plastic vial. Plasma gel tube is not acceptable.
Causes for Rejection
Hemolysis, Lipemia, Icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 14 days |
| Frozen | 180 days |