Beta-2 Microglobulin, Random, Urine
Use
Beta-2 microglobulin is a low-molecular-weight protein that forms the light chain component of class I histocompatibility antigens. It's primarily eliminated through glomerular filtration and its increased urinary excretion is a marker for proximal tubular renal damage. Conditions like Wilson disease, Fanconi syndrome, and exposure to heavy metals such as cadmium and mercury result in elevated levels, often seen in renal tubular damage evaluation and monitoring of toxic exposures.
Special Instructions
Patient should not take multivitamins or dietary supplements containing biotin (vitamin B7) for 12 hours prior to specimen collection. If not ordering electronically, complete and send a Renal Diagnostics Test Request form with the specimen.
Limitations
Proper specimen collection is crucial as degradation of beta-2 microglobulin occurs at pH less than 6. It's essential to maintain a pH between 6 and 8 using sodium hydroxide as a preservative. Results should be interpreted in conjunction with clinical examination, patient history, and other diagnostic findings.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 1953-9
- 1953-9
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
1 mL
Minimum Volume
0.5mL
Container
Plastic, urine tube
Collection Instructions
Patient should empty bladder and drink at least 0.5 liters of water. Collect a random urine specimen within 1 hour and add 1M sodium hydroxide as preservative to maintain a pH between 6 and 8.
Patient Preparation
For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7).
Causes for Rejection
Specimen with pH <6
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 48 hours |
| Frozen | 14 days |