Biliary Tract Malignancy, FISH, Varies
Use
This test is useful for assessing bile duct brushing or hepatobiliary brushing specimens for biliary tract malignancy. It helps to detect cells with chromosomal alterations such as aneuploidy that are indicative of malignancy. Studies show that the sensitivity of FISH to detect malignant cells in biliary brush specimens is superior to that of conventional cytology.
Special Instructions
When this test is ordered, fluorescence in situ hybridization testing will be performed. If performing local cytology in addition to FISH testing, aliquot half of the specimen into another ThinPrep vial before processing. Label each specimen with its specific source.
Limitations
A positive FISH result does not identify the location or type of malignancy. FISH abnormalities may be associated with high-grade dysplasia or carcinoma in situ. The sensitivity of bile duct brushing and bile aspirate cytology is quite low, but FISH has shown increased sensitivity over conventional methods.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 95229-1
- 50397-9
- 95229-1
- 69965-2
- 42349-1
- 31208-2
- 39111-0
- 8100-0
- 33724-6
- 22636-5
- 85069-3
- 18771-6
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
Entire collection
Minimum Volume
Not provided
Container
Separate ThinPrep vial, containing 20 mL PreservCyt or CytoLyt solution for each specimen
Collection Instructions
If performing local cytology in addition to FISH testing, aliquot half of the specimen into another ThinPrep vial before processing the specimen. Label each specimen with the specific source.
Causes for Rejection
Pancreatic mass, Pancreatic cyst, Pancreatic fine-needle aspiration (FNA)
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | preferred |