Bismuth, Blood
Use
This test is useful for determining bismuth toxicity. Bismuth is a component used in various alloys, pigments, and chemical additives, as well as in therapeutic agents, astringents, and antacids like bismuth subsalicylate (Pepto-Bismol). Elevated levels of bismuth in the blood can indicate exposure or toxicity, which may result in various health issues such as nephropathy, encephalopathy, osteoarthropathy, gingivitis, stomatitis, and colitis.
Special Instructions
High concentrations of gadolinium and iodine may interfere with inductively coupled plasma mass spectrometry-based metal tests. Therefore, a specimen should not be collected for 96 hours following the administration of gadolinium- or iodine-containing contrast media. The specimen container must not be opened or used for any other testing before shipping.
Limitations
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration. There are no significant cautionary statements listed; however, improper specimen collection and handling may lead to diagnostic confusion.
New York Approved
Methodology
Mass Spectrometry (ICP-MS)
Biomarkers
LOINC Codes
- 8161-2
- 8161-2
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
0.8 mL
Minimum Volume
0.25 mL
Container
Royal blue-top BD vacutainer with EDTA blood collection tube (3 mL preferred), 6 mL acceptable
Collection Instructions
Send whole blood specimen in the original tube. Do not aliquot.
Patient Preparation
If gadolinium- or iodine-containing contrast media has been administered, do not collect a specimen for 96 hours.
Causes for Rejection
Gross hemolysis, lipemia, and icterus are OK.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 28 days |