Bone Histomorphometry, Consultant Interpretation, Slides Only
Use
Bone histomorphometry is used to diagnose metabolic bone diseases such as renal osteodystrophy, osteomalacia, osteoporosis, and Paget disease. The test is also useful for assessing the effects of therapy, diagnosing aluminum toxicity, and identifying disorders such as iron abnormalities in the bone and hematopoietic system disorders. It utilizes sophisticated techniques such as 2-time interval labeling with tetracycline to directly measure the rate of bone formation.
Special Instructions
The Bone Histomorphometry: Patient Information (T352) form must be completed and sent with the specimen. Slides will be returned 2 weeks after result release. For complete specimen preparation instructions, refer to the Bone Histomorphometry Specimen Preparation (T579) PDF.
Limitations
Mineralization or bone formation rates can only be evaluated if tetracycline has been administered according to a specific schedule prior to biopsy. The preferred biopsy site is the iliac crest. No histomorphometric values are directly provided in the report as it primarily includes interpretation by trained clinical endocrinologists.
Methodology
Other
Biomarkers
LOINC Codes
- 60570-9
- 59465-5
- 51628-6
- 19139-5
- 22633-2
- 80398-1
- 62364-5
Result Turnaround Time
21-26 days
Related Documents
For more information, please review the documents below
Specimen
Tissue
Volume
Not provided
Minimum Volume
Not provided
Container
Plastic slide holder
Collection Instructions
Specimens must include at least 1 Goldner Trichrome-stained slide and 1 hematoxylin and eosin-stained slide. A tetracycline slide should be included if applicable.
Causes for Rejection
Decalcified bone will be rejected.