Bromine - Total, Blood
Use
Measurement of total bromine in whole blood provides guidance in determining exposure levels, with population reference intervals (2.5th–97.5th percentiles) between 1.4 and 8.8 mg/L. Significantly elevated bromide concentrations, particularly above 12 mg/L in workers exposed to methyl bromide, have been associated with increased risk of electroencephalogram disturbances. Background concentrations are diet-dependent and elevated results may reflect environmental contamination.
Special Instructions
Specimens must be collected in trace metal–free containers. The specimen should avoid contact with iodine-containing disinfectants (e.g., Betadine) during venipuncture, and prior exposure to gadolinium or iodine-based contrast media should be avoided for 96 hours before collection. Unexpected elevated results should be confirmed with a second specimen in a trace metal–free container.
Limitations
Specimens unsuitable for elemental testing due to container contamination or collection conditions may yield spurious results. Environmental contamination during collection can elevate elemental measurements. Reference intervals are derived from NMS Labs, and reporting limits are determined per analysis.
Methodology
Mass Spectrometry (Other)
Biomarkers
LOINC Codes
- 42725-2
- 42725-2
Result Turnaround Time
7-11 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL
Minimum Volume
0.7 mL
Container
Royal blue top (Trace metal‑free EDTA)
Collection Instructions
Do not use disinfectants containing iodine, eg, Betadine, during venipuncture. Send whole blood specimen in original tube. Send refrigerated. Avoid gadolinium or iodine‑based contrast media for 96 hours prior to collection.
Causes for Rejection
All specimens will be evaluated by the processing and performing laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 30 days |
| Refrigerated | 30 days |
| Frozen | 365 days |