Buprenorphine and Norbuprenorphine, Random, Urine
Use
This test is useful for monitoring compliance in patients utilizing buprenorphine. It also aids in the detection and confirmation of the illicit use of buprenorphine, providing important information for those in therapy for opioid dependence. Buprenorphine is a partial mu-opioid receptor agonist, known for its utility in substitution therapy for opioid dependence and as an analgesic. The test detects both the parent compound and its metabolite, norbuprenorphine, in urine. The quantification of buprenorphine in urine helps in identifying patients deviating from opioid dependence therapy.
Special Instructions
For situations where chain of custody is required, a Chain of Custody Kit (T282) is available. If urine creatinine is required or adulteration is suspected, an additional Adulterants Survey test may be necessary. STAT requests are not accepted for this test.
Limitations
Urine concentrations of buprenorphine do not correlate well with serum drug levels and are not suitable for therapeutic drug management. Gross hemolysis and gross icterus of the specimen are acceptable.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 69033-9
- 3415-7
- 49753-7
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic urine container
Collection Instructions
Collect a random urine specimen. No preservative. Submitting less than 1 mL will compromise the ability to perform all necessary testing.
Causes for Rejection
Submitting less than 1 mL will compromise the ability to perform all necessary testing.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |