Use

Monitoring of unbound or free carbamazepine levels in patients where total carbamazepine result is within the therapeutic range but the patient is experiencing side effects. It is also useful for monitoring carbamazepine (free) therapy in patients who are uremic. The free drug is the active form and can cross into the brain's interstitial space where it exerts its pharmacological effect. Measurement of free carbamazepine levels is critical in patients with altered protein binding due to conditions like hypoalbuminemia, kidney disease, and the concurrent administration of drugs affecting protein binding.