Casein, IgE, Serum
Use
The Casein, IgE test is useful for establishing a diagnosis of an allergy to casein. It helps in defining the specific allergen responsible for eliciting allergic signs and symptoms, such as allergic responses and anaphylactic episodes. This test is particularly useful for confirming sensitization before initiating immunotherapy and for investigating reaction specificity to various allergens, including insect venom, drugs, or chemical allergens. Testing for IgE antibodies provides insight into the immune response to allergens potentially associated with allergic diseases.
Special Instructions
For a listing of available allergens for testing, see 'Allergens - Immunoglobulin E (IgE) Antibodies' on Mayo Clinic Labs website. If not ordering electronically, complete and send an 'Allergen Test Request' (T236) with the specimen.
Limitations
Testing for IgE antibodies is not useful in patients who have undergone immunotherapy to determine if residual clinical sensitivity remains. Additionally, it is not recommended for patients where medical management does not depend on allergen specificity identification. False positives may occur in patients with significantly elevated serum IgE levels (>2500 kU/L), resulting in nonspecific binding to the allergen solid phases.
FDA ApprovedNew York Approved
Methodology
Immunoassay (FEIA)
Biomarkers
LOINC Codes
- 6062-4
- 6062-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL for every 5 allergens requested
Minimum Volume
For 1 allergen: 0.3 mL
Container
Plastic vial
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Causes for Rejection
Gross hemolysis: OK, Gross lipemia: OK
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 14 days |
| Frozen | 90 days |