CD279 (PD-1) Immunostain, Technical Component Only

Casandra

Casandra Test Code MC48088Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID CD279CPT Codes 88341, 88342

CD279 (PD-1) Immunostain, Technical Component Only

Clinical Use

Use

The test is useful for identifying follicular T helper cells and phenotyping angioimmunoblastic T-cell lymphoma. CD279, also known as programmed cell death 1 (PD-1), is an immunoregulatory receptor highly expressed by follicular T helper cells, and its expression has been noted in angioimmunoblastic T-cell lymphoma. This molecule, interacting with PD-L1, attenuates T-cell activation, supporting a diagnosis in a nodular lymphocyte-predominant Hodgkin lymphoma context.

Special Instructions

This test provides only the technical component of the stain and does not include pathologist interpretation. When ordered with a pathology consultation, the technical component stains will be canceled. Attaching the appropriate labels to the transport container is necessary for shipment.

Limitations

This test does not provide an interpretation; it requires separate ordering of a pathology consultation for full diagnostic evaluation. Stability of the slide and immunoreactivity are affected by environmental factors. Best practices include limiting slide storage time, exposure to humidity, and proper handling to avoid loss of staining quality.

Test Details

FDA Approved

New York Approved

Methodology

Immunoassay (IHC)

Biomarkers

PD-1

Protein

IHC • Expression • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

Order only;no result

Result Turnaround Time

1-3 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

See Specimen Required

Container

Immunostain Technical Only Envelope

Collection Instructions

Preferred specimens include formalin-fixed, paraffin-embedded tissue blocks or 2 unstained, positively charged glass slides per test ordered, with sections 4-microns thick.