CD279 (PD-1) Immunostain, Technical Component Only
Use
The test is useful for identifying follicular T helper cells and phenotyping angioimmunoblastic T-cell lymphoma. CD279, also known as programmed cell death 1 (PD-1), is an immunoregulatory receptor highly expressed by follicular T helper cells, and its expression has been noted in angioimmunoblastic T-cell lymphoma. This molecule, interacting with PD-L1, attenuates T-cell activation, supporting a diagnosis in a nodular lymphocyte-predominant Hodgkin lymphoma context.
Special Instructions
Not provided.
Limitations
This test does not provide an interpretation; it requires separate ordering of a pathology consultation for full diagnostic evaluation. Stability of the slide and immunoreactivity are affected by environmental factors. Best practices include limiting slide storage time, exposure to humidity, and proper handling to avoid loss of staining quality.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
PD-1
Protein
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
See Specimen Required
Container
Immunostain Technical Only Envelope
Collection Instructions
Preferred specimens include formalin-fixed, paraffin-embedded tissue blocks or 2 unstained, positively charged glass slides per test ordered, with sections 4-microns thick.
Storage Instructions
Slides should be minimized for storage after unpackaging and kept away from high humidity and heat.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |