CD56 Immunostain, Technical Component Only
Use
CD56 (cluster of differentiation 56) is an adhesion molecule mediating homophilic and heterophilic adhesion in neurons, natural killer cells, and a small subset of CD4- and CD8-positive T cells. It is expressed in tumors with neuroendocrine differentiation, such as small cell lung carcinoma and neural-derived tumors, or natural killer cell lineage, such as a subset of lymphomas. CD56 immunostain aids in identifying tumors with these characteristics and may also show strong staining in ganglion cells and nerves in normal small intestine.
Special Instructions
Not provided.
Limitations
This test does not include pathologist interpretation, only the technical performance of the stain. Interpretation should be performed considering the patient's clinical history and other diagnostic tests by a qualified pathologist. Factors such as the age of a paraffin section and the storage conditions of slides can affect immunoreactivity and staining consistency.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
CD56
Protein
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Preferred specimen includes formalin-fixed, paraffin-embedded tissue block or 2 unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |
| Refrigerated | Refrigerated |