Casandra

Casandra Test Code MC14769Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID GLICPCPT Codes 86355, 86356, 86357, 86359, 86360

CD8 T-Cell Immune Competence Panel, Global, Whole Blood

Clinical Use

Use

This test is used for determining over immunosuppression within the CD8 T-cell compartment, particularly in transplant recipients and patients with autoimmune disorders receiving immunosuppressants. It assesses CD8 T-cell function by measuring intracellular IFN-gamma expression and surface CD107a/CD107b expression, providing insight into immune competence, especially after induction immunosuppression or for monitoring maintenance therapy to ensure adequate T-cell function without over-immunosuppression. This helps in balancing the risk of graft rejection and infectious complications.

Special Instructions

Not provided.

Limitations

The assay is specific to CD8 T cells and does not provide information on overall T-cell competence. Impairment due to over-immunosuppression may result in decreased IFN-gamma production and increased infection risk. The assay may not correlate directly with drug levels due to individual pharmacokinetic variations, making functional assessment critical.

Test Details