Use

This test is used for determining over immunosuppression within the CD8 T-cell compartment, particularly in transplant recipients and patients with autoimmune disorders receiving immunosuppressants. It assesses CD8 T-cell function by measuring intracellular IFN-gamma expression and surface CD107a/CD107b expression, providing insight into immune competence, especially after induction immunosuppression or for monitoring maintenance therapy to ensure adequate T-cell function without over-immunosuppression. This helps in balancing the risk of graft rejection and infectious complications.