Celiac Disease Comprehensive Cascade, Serum and Whole Blood
Use
The Celiac Disease Comprehensive Cascade is used for evaluating patients suspected of having celiac disease. This test includes an algorithmic evaluation encompassing human leukocyte antigen (HLA) typing. It helps in identifying individuals with a high probability of celiac disease, which can assist in deciding the need for invasive procedures like a small intestinal biopsy. The test checks for various serologic markers that can increase the probability of diagnosing celiac disease. It is especially useful for individuals with family members who have celiac disease and may have genetic susceptibility due to specific HLA markers.
Special Instructions
Not provided.
Limitations
This cascade should not be solely relied upon to establish a diagnosis of celiac disease. It is used to identify patients with an increased probability of having celiac disease for whom a small intestinal biopsy is recommended. HLA typing identifies genetic predisposition but does not confirm the disease. Negative serologic results do not exclude celiac disease, especially in patients who have started a gluten-free diet.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 94493-4 - Celiac IgA + HLA + Sero Bld/T
- 2458-8 - IgA SerPl-mCnc
- 94495-9 - HLA-DQA1
- 53938-7 - HLA-DQB1
- 48767-8 - Annotation comment Imp
- 69048-7 - Immunologist review
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
3 mL
Container
Yellow top (ACD solution A or B)
Collection Instructions
Send whole blood in original tube. Do not aliquot.
Causes for Rejection
Gross hemolysis, Gross lipemia, Gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | Preferred |
| Frozen | 21 days |