Celiac Disease Gluten-Free Cascade, Serum and Whole Blood

Casandra

Casandra Test Code MC62729Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID CDGFCPT Codes 81376, 82784, 86231, 86258, 86364

Celiac Disease Gluten-Free Cascade, Serum and Whole Blood

Clinical Use

Use

Evaluating patients suspected of having celiac disease who are currently (or were recently) on a gluten-free diet. This cascade should not be used in patients for whom HLA DQ2/DQ8 typing has already been performed. It is suitable for patients who are on a gluten-free diet, as traditional serologic tests may yield false-negative results in these individuals. Cascade testing ensures that testing proceeds in an algorithmic fashion, minimizing unnecessary tests and costs.

Special Instructions

Not provided.

Limitations

Genetic markers HLA-DQ2 and HLA-DQ8 are required but not sufficient for the development of celiac disease; not all individuals with these alleles will develop celiac disease. A small intestinal biopsy remains the gold standard for diagnosis. IgA deficiency must be considered as it may require additional IgG antibody testing. Results must be interpreted in the context of clinical symptoms and serological findings.

Test Details

New York Approved