Cerebrospinal Fluid (CSF) IgG Index, Spinal Fluid
Use
The Cerebrospinal Fluid (CSF) IgG Index test is useful for aiding in the diagnosis of multiple sclerosis and other central nervous system inflammatory conditions. The test helps detect the elevation of IgG in the cerebrospinal fluid, which is commonly associated with inflammatory diseases of the central nervous system such as multiple sclerosis, neurosyphilis, acute inflammatory polyradiculoneuropathy, and subacute sclerosing panencephalitis. It provides a mathematical indicator of the relative increase in IgG synthesis within the central nervous system, making it a valuable tool in identifying CNS inflammatory diseases.
Special Instructions
Not provided.
Limitations
The test can be falsely elevated in conditions other than multiple sclerosis, such as neurosyphilis, acute inflammatory polyradiculoneuropathy, and subacute sclerosing panencephalitis. The cerebrospinal fluid IgG index reflects relative synthesis of IgG and may be influenced by blood-brain barrier permeability. It is essential that comprehensive clinical correlation be done alongside the test to ensure accurate diagnosis and exclude confounding factors.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Nephelometry)
Biomarkers
LOINC Codes
- 14117-6 - IgG/Alb clear Ser+CSF-Rto
- 2464-6 - IgG CSF-mCnc
- 1746-7 - Albumin CSF-mCnc
- 2470-3 - IgG/Alb CSF
- 14116-8 - IgG Synth Rate Ser+CSF Calc-mRate
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.5 mL
Container
Sterile vial
Collection Instructions
Label specimen as spinal fluid.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |