Ceruloplasmin, Serum

Casandra

Casandra Test Code MC62128Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID CERSCPT Code 82390

Clinical Use

Use

Ceruloplasmin is a positive acute-phase reactant and a copper-binding protein that accounts for over 95% of serum copper in normal adults. Ceruloplasmin is measured primarily to assist with a diagnosis of Wilson disease. Other indications include Menkes disease, dietary copper insufficiency, and risk of cardiovascular disease. Wilson disease is a rare inherited disorder of copper transport that results in low serum copper and ceruloplasmin and accumulation of copper in various tissues. The pathological accumulation of copper in the liver, brain, cornea, and kidney causes cirrhosis, neuropsychiatric symptoms, Kayser-Fleischer rings, and hematuria/proteinuria, respectively.

Special Instructions

Fasting for 4 hours is preferred but not required. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen: Benign Hematology Test Request, General Request, Gastroenterology and Hepatology Test Request, or Biochemical Genetics Test Request.

Limitations

Ceruloplasmin is a positive acute-phase reactant; therefore, levels are elevated in cases of inflammation. Consequently, ceruloplasmin levels are not always extremely low in patients with Wilson disease. Values vary considerably from patient to patient and may be in the normal range in some patients with Wilson disease. Birth control pills and pregnancy may increase ceruloplasmin levels.

Test Details

New York Approved