Ceruloplasmin, Serum
Use
Ceruloplasmin is a positive acute-phase reactant and a copper-binding protein that accounts for over 95% of serum copper in normal adults. Ceruloplasmin is measured primarily to assist with a diagnosis of Wilson disease. Other indications include Menkes disease, dietary copper insufficiency, and risk of cardiovascular disease. Wilson disease is a rare inherited disorder of copper transport that results in low serum copper and ceruloplasmin and accumulation of copper in various tissues. The pathological accumulation of copper in the liver, brain, cornea, and kidney causes cirrhosis, neuropsychiatric symptoms, Kayser-Fleischer rings, and hematuria/proteinuria, respectively.
Special Instructions
Not provided.
Limitations
Ceruloplasmin is a positive acute-phase reactant; therefore, levels are elevated in cases of inflammation. Consequently, ceruloplasmin levels are not always extremely low in patients with Wilson disease. Values vary considerably from patient to patient and may be in the normal range in some patients with Wilson disease. Birth control pills and pregnancy may increase ceruloplasmin levels.
New York Approved
Methodology
Immunoassay (Nephelometric Assay)
Biomarkers
Ceruloplasmin
Protein
LOINC Codes
- 2064-4 - Ceruloplasmin SerPl-mCnc
- 2064-4 - Ceruloplasmin SerPl-mCnc
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Preferred: Serum gel; Acceptable: Red top; Submission: Plastic vial (false-bottom vials are not acceptable)
Collection Instructions
Centrifuge and aliquot serum into a plastic vial.
Patient Preparation
Fasting for 4 hours is preferred but not required.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 30 days |