Chromatin (Nucleosomal) Antibody
Use
The Chromatin (Nucleosomal) Antibody test is used for the detection of antibodies against chromatin, which is a complex of DNA and proteins found in the cell nucleus. The presence of these antibodies can be indicative of autoimmune conditions, such as systemic lupus erythematosus (SLE) and other connective tissue diseases. This test helps in the assessment and diagnosis of these autoimmune diseases and can guide treatment decisions and monitoring of disease activity.
Special Instructions
The test requires a blood draw in a plain red-top tube, with a serum gel tube being acceptable as well. After collection, the sample should be spun down and 1 mL of serum should be sent refrigerated in a plastic vial. The test is performed at Quest Diagnostics Nichols Institute and is available for order in New York State.
Limitations
This test is limited to the detection of chromatin antibodies and cannot differentiate between different types or specificities of nuclear antibodies. Results outside the reference range should be interpreted with caution and in the context of other diagnostic findings. Gross hemolysis, lipemia, or icterus can lead to sample rejection and may affect test accuracy.
New York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 34416-8
- 34416-8
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plastic vial
Collection Instructions
Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 7 days |
| Frozen | 30 days |