Chromosomal Microarray, Hematologic Disorders, Varies

Casandra

Casandra Test Code MC96330Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID CMAHCPT Code 81277

Chromosomal Microarray, Hematologic Disorders, Varies

Clinical Use

Use

Chromosomal microarray (CMA) is crucial in identifying chromosome abnormalities in hematologic disorders, providing diagnostic, prognostic, and therapeutic insights. It enhances detection rates of genetic changes not visible by conventional chromosome analysis or FISH, using over 2 million copy number probes and about 750,000 SNP probes. This test aids in defining the size, breakpoints, and gene content of genetic changes, identifying cryptic imbalances, and assessing regions of loss of heterozygosity which are prevalent in neoplasia.

Special Instructions

The test is not suitable for detecting constitutional/congenital copy number changes or regions of excessive homozygosity. When ordered for such reasons, the test is canceled and replaced with a more appropriate one. A reason for testing must be included. DNA extraction will be performed initially, with possible subsequent karyotype or FISH tests upon request.

Limitations

This test is not FDA approved and should complement existing clinical and pathologic data. It cannot detect balanced chromosomal rearrangements, point mutations, small deletions, or insertions below assay resolution. Low-level clones may go undetected, and tetraploidy is not identified. The test can yield incidental findings unrelated to the initial testing intent.

Test Details

New York Approved