Chromosomal Microarray, Tumor, Fresh or Frozen
Use
Genomic characterization of tumor for copy number imbalances and loss of heterozygosity is essential in assisting diagnosis and classification of malignant neoplasms, including hematolymphoid malignancies. This genetic information plays a significant role in evaluating the prognosis of patients with malignant tumors. Chromosomal microarray (CMA) analysis detects genetic changes not identified by conventional chromosome analysis or fluorescence in situ hybridization (FISH) studies, thus improving diagnostic yield.
Special Instructions
This test is not performed on formalin-fixed, paraffin-embedded (FFPE) specimens. Submitting FFPE specimens will lead to test cancellation and replacement with the appropriate CMAPT test. Shipping instructions emphasize using Express Mail if not on a courier service. Providing a reason for testing and a pathology report is crucial for test performance and result interpretation.
Limitations
The test does not identify balanced chromosome rearrangements or detect point mutations, small insertions, deletions, trinucleotide repeat expansions, or other variants such as epigenetic changes. It may not detect mosaicism in a small proportion of cells, making it unsuitable for minimal residual disease monitoring or specimens with less than 20% tumor content. The test may also reveal incidental findings unrelated to the primary referral reason.
New York Approved
Methodology
Microarray (SNP Array)
Biomarkers
LOINC Codes
- 94087-4
- 50397-9
- 62356-1
- 69965-2
- 42349-1
- 31208-2
- 85069-3
- 48767-8
- 18771-6
Result Turnaround Time
10-21 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue
Volume
0.5-3 cm(3) or larger
Minimum Volume
3 cm(3)
Container
Sterile container with sterile Hank's balanced salt solution, Ringer's solution, or normal saline
Collection Instructions
1. Wash biopsy site with an antiseptic soap. 2. Thoroughly rinse area with sterile water. 3. Do not use alcohol or iodine preparations. 4. A local anesthetic may be used. 5. Biopsy specimens are best taken by punch biopsy to include full thickness of dermis.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |