Chromosome Analysis, Hematologic Disorders, Bone Marrow
Use
Assisting in the diagnosis and classification of certain malignant hematological disorders in bone marrow specimens, evaluating prognosis in patients with these disorders, monitoring effects of treatment, and monitoring patients in remission. This test is not recommended for plasma cell neoplasms due to limited clinical utility.
Special Instructions
Not provided.
Limitations
B lymphocytes do not proliferate well in cell culture, possibly affecting the success of conventional chromosome studies. Technical factors like insufficient bone marrow specimen and improper anticoagulant usage may cause diagnostic confusion. Biological factors may include abnormalities missed due to sampling error and neoplastic cells not dividing or not present in bone marrow.
New York Approved
Methodology
Chromosomal / Cytogenetics
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 81861-7 - Karyotyp Mar
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 33893-9 - Karyotyp Mar
- 42349-1
- 31208-2 - Specimen source
- 85069-3 - Lab test method
- 62359-5 - Chrom banding method
- 48767-8 - Annotation comment Imp
- 18771-6 - Provider signing name
Result Turnaround Time
9-11 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 to 3 mL
Minimum Volume
Not provided
Container
Yellow top (ACD); Green top (sodium heparin) or lavender top (EDTA) acceptable
Collection Instructions
It is preferable to send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow.
Storage Instructions
Ambient (preferred); Refrigerated acceptable
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.