Chromosome Analysis, Hematologic Disorders, Children's Oncology Group Enrollment Testing, Blood
Use
Evaluation of pediatric blood specimens for chromosomal abnormalities associated with hematologic malignancies. This test is critical for diagnostic and prognostic purposes in patients being considered for enrollment in Children's Oncology Group clinical trials and research protocols.
Special Instructions
Not provided.
Limitations
The test is not useful for congenital disorders. Chromosome studies on blood may be less sensitive compared to bone marrow, with a lower chance of finding metaphases. Subtle structural chromosome abnormalities may not be detected by conventional chromosome analysis. A lack of apparent abnormal clone might result from a lack of circulating abnormal cells rather than the absence of disease.
New York Approved
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
LOINC Codes
- 62386-8 - Chrom anl summary pnl
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 85069-3 - Lab test method
- 62359-5 - Chrom banding method
- 48767-8 - Annotation comment Imp
- 18771-6 - Provider signing name
Result Turnaround Time
9-11 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
3 mL
Container
Yellow top (ACD)
Collection Instructions
Invert several times to mix blood.
Storage Instructions
Ambient (preferred), Refrigerated acceptable
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.