Chromosome Analysis, Hematologic Disorders, Children's Oncology Group Enrollment Testing, Bone Marrow
Use
Evaluation of pediatric bone marrow specimens for chromosomal abnormalities associated with hematologic malignancies for diagnostic and prognostic purposes in patients being considered for enrollment in Children's Oncology Group clinical trials and research protocols using bone marrow specimens.
Special Instructions
Not provided.
Limitations
In some cases, fluorescence in situ hybridization studies may detect some disorders better than conventional chromosome studies. Insufficient bone marrow specimen, use of an improper anticoagulant or improperly mixing the blood with the anticoagulant, clotted bone marrow specimen, excessive transport time, exposure of the specimen to extreme temperature, and not processing the bone marrow as indicated before shipping can lead to issues. Abnormalities might be missed due to sampling error or subtle structural chromosome abnormalities might not be detected by conventional chromosome analysis. Neoplastic cells might not be dividing or not present in bone marrow.
New York Approved
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 62386-8 - Chrom anl summary pnl
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 62356-1 - Chrom analy result (ISCN)
- 42349-1
- 31208-2 - Specimen source
- 85069-3 - Lab test method
- 62359-5 - Chrom banding method
- 48767-8 - Annotation comment Imp
- 18771-6 - Provider signing name
Result Turnaround Time
9-11 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
4 mL
Minimum Volume
2 mL
Container
Preferred: Yellow top (ACD); Acceptable: Green top (sodium heparin) or lavender top (EDTA)
Collection Instructions
It is preferable to send the first aspirate from the bone marrow collection. Invert several times to mix bone marrow.
Causes for Rejection
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |