Chronic Hepatitis B Screen, Serum
Use
This test is used for the diagnosis and evaluation of patients at risk for or suspected of having chronic hepatitis B. It helps in determining the presence of hepatitis B surface antigen (HBsAg) which is indicative of acute or chronic hepatitis B or a chronic hepatitis B virus (HBV) carrier state. The presence of HBe antigen or detectable HBV DNA usually accompanies HBsAg, confirming HBV replication and infectivity.
Special Instructions
Not provided.
Limitations
This test is not offered as a screening or confirmatory test for blood donor specimens. It is not useful during the 'window period' of acute hepatitis B infection and not for stand-alone prenatal screening of HBsAg in pregnant women. False results can occur in individuals taking high-dose biotin supplements. Performance characteristics not established in pregnant women or certain populations like immunocompromised patients and those with certain specimen characteristics.
New York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
Hepatitis B surface antigen (HBsAg)
Protein
LOINC Codes
- 5196-1 - HBV surface Ag SerPl Ql IA
- 5196-1 - HBV surface Ag SerPl Ql IA
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.2 mL
Minimum Volume
0.9 mL
Container
Plastic vial
Collection Instructions
Centrifuge blood collection tube per manufacturer's instructions (e.g., centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).
Patient Preparation
For 24 hours before specimen collection, patient should not take multivitamins or dietary supplements (e.g., hair, skin, and nail supplements) containing biotin (vitamin B7).
Causes for Rejection
Gross hemolysis, gross lipemia, gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 6 days |
| Frozen | 90 days |