Chronic Lymphocytic Leukemia, Diagnostic FISH, Varies
Use
This test is used to detect recurrent common chromosome abnormalities in patients with chronic lymphocytic leukemia (CLL) using a laboratory-designated probe set algorithm. It can also distinguish between patients with 11;14 translocations who have the leukemic phase of mantle cell lymphoma and those with CLL. Additionally, it detects patients with atypical CLL with translocations between IGH and BCL3, and evaluates specimens where chromosome studies are unsuccessful.
Special Instructions
Not provided.
Limitations
This test has not been approved by the US Food and Drug Administration. It is an adjunct to clinical and pathologic information and should not replace conventional chromosome studies that detect other hematological disorder abnormalities. FISH is not a substitute for these studies. If no FISH signals are observed post-hybridization, results will reflect a lack of FISH results.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101788-8 - CLL gene rearrange Bld/Mar FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
2 mL
Container
Yellow top (ACD), Green top (sodium heparin), or Lavender top (EDTA)
Collection Instructions
Invert several times to mix blood. Send whole blood in original tube. Do not aliquot.
Causes for Rejection
Fresh tissue