Chronic Lymphocytic Leukemia, Diagnostic FISH, Varies

Casandra

Casandra Test Code MC21329Version 1 (DRAFT)

Performing Lab

Lab Mayo Clinic LabLab Test ID CLLDFCPT Codes 88271, 88275, 88291

Chronic Lymphocytic Leukemia, Diagnostic FISH, Varies

Clinical Use

Use

This test is used to detect recurrent common chromosome abnormalities in patients with chronic lymphocytic leukemia (CLL) using a laboratory-designated probe set algorithm. It can also distinguish between patients with 11;14 translocations who have the leukemic phase of mantle cell lymphoma and those with CLL. Additionally, it detects patients with atypical CLL with translocations between IGH and BCL3, and evaluates specimens where chromosome studies are unsuccessful.

Special Instructions

A reason for testing must be provided. If this information is not provided, Mayo Clinic Laboratories may enter an appropriate indication for testing. A flow cytometry or bone marrow pathology report should accompany each specimen, though testing won't be rejected without it, although interpretation could be delayed.

Limitations

This test has not been approved by the US Food and Drug Administration. It is an adjunct to clinical and pathologic information and should not replace conventional chromosome studies that detect other hematological disorder abnormalities. FISH is not a substitute for these studies. If no FISH signals are observed post-hybridization, results will reflect a lack of FISH results.

Test Details

New York Approved