Chronic Lymphocytic Leukemia, Specified FISH, Varies
Use
Detecting recurrent common chromosome abnormalities in patients with chronic lymphocytic leukemia (CLL) using client-specified probe sets. Distinguishing patients with 11;14 translocations who have the leukemic phase of mantle cell lymphoma from those who have CLL. Detecting patients with atypical CLL with translocations between IGH and BCL3. Evaluating specimens in which chromosome studies are unsuccessful. This test uses fluorescence in situ hybridization (FISH) to provide important insights into the chromosomal abnormalities associated with CLL, which can significantly influence clinical management and prognosis.
Special Instructions
Not provided.
Limitations
This FISH assay is not a substitute for conventional chromosome studies, which can detect abnormalities associated with other hematological disorders. The test's utility is limited to detecting chromosome abnormalities known to be associated with CLL, and it does not detect abnormalities not included in the specific probe set requested. The test is not FDA approved and should be used as an adjunct to clinical and pathologic information. Improper specimen collection and handling or inappropriate test selection can cause diagnostic confusion.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 101920-7 - CLL gene targeted rearrange Bld/Mar FISH
- 50397-9 - Mol dx interp Bld/T Ql
- 69965-2 - Clinical cytogeneticist review
- 93356-4 - Cells w cytogenetic abnl Bld/T
- 62356-1 - Chrom analy result (ISCN)
- 31208-2 - Specimen source
- 85069-3 - Lab test method
- 48767-8 - Annotation comment Imp
- 62364-5 - Test performance info Spec
- 18771-6 - Provider signing name
- 78040-3 - FISH probe target gene Lab Device
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
6 mL
Minimum Volume
2 mL
Container
Yellow top (ACD) – Preferred; Green top (sodium heparin) or lavender top (EDTA) – Acceptable
Collection Instructions
Invert several times to mix blood. Send whole blood in original tube. Do not aliquot.
Storage Instructions
Ambient (preferred); Refrigerated – Acceptable
Causes for Rejection
Fresh tissue - Reject