Claudin-1 Immunostain, Technical Component Only
Use
Claudin proteins are essential tight junction-associated proteins that prevent leakage of substances between cells. Their differential expression is observed in various epithelial and soft tissue neoplasms. Claudin-1, in particular, shows strong expression in squamous epithelial cells and may have reduced expression in some invasive breast lesions compared to benign forms. The test is useful in identifying neoplasms through claudin-1 expression patterns, being positive in about 30% to 50% of certain soft tissue and intramucosal perineuriomas, and more frequently expressed in gastric intestinal-type adenocarcinomas compared to diffuse types.
Special Instructions
This test only includes the technical performance of the stain and does not provide a pathologist interpretation. Technical component stains should not be ordered with PATHC / Pathology Consultation. If ordered together, technical component stains will be canceled and performed at the discretion of the reviewing pathologist, incurring additional charges.
Limitations
The test does not include interpretation, only technical performance of the stain. If an interpretation is necessary, PATHC / Pathology Consultation should be ordered. Factors affecting immunoreactivity include the age of cut paraffin sections and environmental conditions affecting slide charge, leading to inconsistent staining.
FDA ApprovedNew York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- Order only;no result
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Immunostain Technical Only Envelope
Collection Instructions
Use formalin-fixed, paraffin-embedded tissue block OR 2 unstained, positively charged glass slides per test (4-micron sections). Attach specific labels to the transport container.
Causes for Rejection
Wet/frozen tissue, cytology smears, nonformalin fixed tissue, nonparaffin embedded tissue, noncharged slides, ProbeOn slides, Snowcoat slides will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient (preferred) |