Use

Claudin proteins are essential tight junction-associated proteins that prevent leakage of substances between cells. Their differential expression is observed in various epithelial and soft tissue neoplasms. Claudin-1, in particular, shows strong expression in squamous epithelial cells and may have reduced expression in some invasive breast lesions compared to benign forms. The test is useful in identifying neoplasms through claudin-1 expression patterns, being positive in about 30% to 50% of certain soft tissue and intramucosal perineuriomas, and more frequently expressed in gastric intestinal-type adenocarcinomas compared to diffuse types.