Use

The Coagulation Factor XI Activity Assay is useful for diagnosing deficiency of coagulation factor XI, which may cause prolonged activated partial thromboplastin time. Factor XI is synthesized in the liver and is a component of the intrinsic coagulation pathway. Activation of factor XI leads to the activation of factor IX to IXa. Deficiency of factor XI is associated with mild bleeding diathesis and is more prevalent among individuals of Ashkenazi Jewish descent. Evaluating factor XI levels is crucial in the context of both congenital and acquired deficiencies, which may have implications for bleeding risk and management.