Cobalt/Creatinine Ratio, Random, Urine
Use
This assay is useful for detecting cobalt exposure via a random urine collection and for monitoring metallic prosthetic implant wear. It is explicitly noted that this test is not useful for assessing vitamin B12 activity.
Special Instructions
Specimen collection procedures require ultraclean specimen collection and handling with special collection tubes in an ultraclean facility to avoid misleading elevated urine cobalt results. Patient preparation instructions note that high concentrations of gadolinium‑ or iodine‑containing contrast media may interfere and a specimen should not be collected within 96 hours of administration.
Limitations
Due to potential interference from improper collection, handling, or contamination by contrast media, elevated urine cobalt results may be incidental and misleading without rigorous ultraclean procedures.
New York Approved
Methodology
Mass Spectrometry (LC-MS/MS)
Biomarkers
LOINC Codes
- 13468-4
- 13468-4
- 2161-8
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
3 mL
Minimum Volume
2 mL
Container
Clean, plastic urine collection container; submission in plastic, 10‑mL urine tube or clean plastic aliquot container with no metal cap or glued insert
Collection Instructions
Collect a random urine specimen using ultraclean techniques; follow Metals Analysis Specimen Collection and Transport instructions; avoid gadolinium‑ or iodine contrast contamination within 96 hours
Patient Preparation
Avoid collection for 96 hours after gadolinium‑ or iodine‑containing contrast media administration
Causes for Rejection
Specimens that are not ultraclean or contaminated may yield misleading results; all specimens evaluated for suitability
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 28 days |
| Frozen | 28 days |